[Physicochemical and biological properties of human placental amniotic interferon]. / Izuchenie fiziko-khimicheskikh i biologicheskikh svoistv chelovecheskogo platsentarnogo amnioticheskogo interferona.
Vopr Virusol
; 30(6): 693-7, 1985.
Article
en Ru
| MEDLINE
| ID: mdl-2420070
The possibility of generating large quantities of highly active interferon from human placenta amniotic membrane (plaferon) has been demonstrated. Plaferon is innocuous and nonreactogenic in experimental models and has an antiviral effect of wide spectrum. The activity is resistant to DNase, RNase, lipase, and stable at pH 2. A polyclonal serum to human leukocyte interferon and monoclonal NK-2 antibody did not inhibit the antiviral activity of plaferon. The level of hormones in plaferon and leukocyte interferon preparations was practically similar. In diploid cultures of human fibroblasts the antiviral condition under the effect of plaferon developed slower than under the effect of leukocyte interferon.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Interferones
/
Amnios
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
Ru
Revista:
Vopr Virusol
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Rusia