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Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression.
Trudu, Matteo; Janas, Sylvie; Lanzani, Chiara; Debaix, Huguette; Schaeffer, Céline; Ikehata, Masami; Citterio, Lorena; Demaretz, Sylvie; Trevisani, Francesco; Ristagno, Giuseppe; Glaudemans, Bob; Laghmani, Kamel; Dell'Antonio, Giacomo; Loffing, Johannes; Rastaldi, Maria P; Manunta, Paolo; Devuyst, Olivier; Rampoldi, Luca.
Afiliación
  • Trudu M; Dulbecco Telethon Institute, c/o Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
  • Janas S; Institute of Physiology, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
  • Lanzani C; Division of Nephrology, UCL Medical School, Brussels, Belgium.
  • Debaix H; Division of Nephrology and Dialysis, San Raffaele Scientific Institute, Milan, Italy.
  • Schaeffer C; Institute of Physiology, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
  • Ikehata M; Division of Nephrology, UCL Medical School, Brussels, Belgium.
  • Citterio L; Dulbecco Telethon Institute, c/o Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
  • Demaretz S; Renal Research Laboratory, Fondazione IRCCS Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy.
  • Trevisani F; Division of Nephrology and Dialysis, San Raffaele Scientific Institute, Milan, Italy.
  • Ristagno G; INSERM, UMRS 872, Paris, France.
  • Glaudemans B; University Vita-Salute San Raffaele, Milan, Italy.
  • Laghmani K; Department of Cardiovascular Research, Istituto di Ricerca Farmacologica Mario Negri, Milan, Italy.
  • Dell'Antonio G; Institute of Physiology, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
  • Loffing J; Department of Pathology, San Raffaele Scientific Institute, Milan, Italy.
  • Manunta P; Institute of Anatomy, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
  • Devuyst O; Renal Research Laboratory, Fondazione IRCCS Ospedale Maggiore Policlinico & Fondazione D'Amico per la Ricerca sulle Malattie Renali, Milan, Italy.
  • Rampoldi L; University Vita-Salute San Raffaele, Milan, Italy.
Nat Med ; 19(12): 1655-60, 2013 Dec.
Article en En | MEDLINE | ID: mdl-24185693

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Regiones Promotoras Genéticas / Insuficiencia Renal Crónica / Uromodulina / Hipertensión Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2013 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Regiones Promotoras Genéticas / Insuficiencia Renal Crónica / Uromodulina / Hipertensión Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2013 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos