Effect of uremic serum and uremic toxins on drug metabolism in human microsomes.

Volpe, Donna A; Tobin, Grainne A; Tavakkoli, Fatemeh; Dowling, Thomas C; Light, Paul D; Parker, Robert J

Volpe, Donna A; Tobin, Grainne A; Tavakkoli, Fatemeh; Dowling, Thomas C; Light, Paul D; Parker, Robert J.

Afiliación

Volpe DA; Division of Drug Safety Research, Food and Drug Administration, Silver Spring, MD, USA. Electronic address: donna.volpe@fda.hhs.gov.
Tobin GA; Division of Drug Safety Research, Food and Drug Administration, Silver Spring, MD, USA.
Tavakkoli F; School of Pharmacy, University of Maryland, Baltimore, MD, USA.
Dowling TC; School of Pharmacy, University of Maryland, Baltimore, MD, USA.
Light PD; School of Medicine, University of Maryland, Baltimore, MD, USA.
Parker RJ; Division of Drug Safety Research, Food and Drug Administration, Silver Spring, MD, USA.

Regul Toxicol Pharmacol ; 68(2): 297-303, 2014 Mar.

Article en En | MEDLINE | ID: mdl-24184159

Asunto(s)

Microsomas Hepáticos/metabolismo; Diálisis Renal; Toxinas Biológicas/metabolismo; Uremia/metabolismo; Adulto; Hidrocarburo de Aril Hidroxilasas/metabolismo; Bupropión/metabolismo; Citocromo P-450 CYP2B6; Citocromo P-450 CYP3A/metabolismo; Femenino; Humanos; Fallo Renal Crónico/terapia; Masculino; Persona de Mediana Edad; Testosterona/metabolismo

Palabras clave

Chronic renal failure; Metabolism; Uremic serum; Uremic toxins

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxinas Biológicas / Uremia / Microsomas Hepáticos / Diálisis Renal Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Regul Toxicol Pharmacol Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos

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