Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: considerations of biological relevance of tumour type, data quality and uncertainty assessment.

Edler, Lutz; Hart, Andy; Greaves, Peter; Carthew, Philip; Coulet, Myriam; Boobis, Alan; Williams, Gary M; Smith, Benjamin

Edler, Lutz; Hart, Andy; Greaves, Peter; Carthew, Philip; Coulet, Myriam; Boobis, Alan; Williams, Gary M; Smith, Benjamin.

Afiliación

Edler L; German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address: edler@dkfz.de.
Hart A; The Food and Environment Research Agency - FERA, Sand Hutton, YO41 1LZ York, United Kingdom. Electronic address: andy.hart@fera.gsi.gov.uk.
Greaves P; Department of Cancer Studies and Molecular Medicine, University of Leicester, LE2 7LX Leicester, United Kingdom. Electronic address: pg29@leicester.ac.uk.
Carthew P; Unilever, Colworth House Sharnbrook, MK44 1LQ Bedfordshire, United Kingdom. Electronic address: philip.carthew@unilever.com.
Coulet M; Nestlé Research Centre, Vers-Chez-Les-Blanc, 1000 Lausanne, Switzerland. Electronic address: myriam.coulet@rdls.nestle.com.
Boobis A; Imperial College, Hammersmith Campus, Ducane Road, W12 0NN London, United Kingdom. Electronic address: a.boobis@imperial.ac.uk.
Williams GM; New York Medical College, Basic Science Building, Room 413, Valhalla, NY 10595, United States. Electronic address: gary_williams@nymc.edu.
Smith B; Firmenich, Rue de la Bergere 7, 1217-Meyrin 2, Switzerland. Electronic address: benjamin.smith@firmenich.com.

Food Chem Toxicol ; 70: 264-89, 2014 Aug.

Article en En | MEDLINE | ID: mdl-24176677

Asunto(s)

Carcinógenos/toxicidad; Daño del ADN/efectos de los fármacos; Incertidumbre; Animales; Bases de Datos Factuales; Modelos Animales de Enfermedad; Relación Dosis-Respuesta a Droga; Sustancias Peligrosas/toxicidad; Humanos; Modelos Biológicos; Modelos Estadísticos; Neoplasias/inducido químicamente; Neoplasias/patología; Estándares de Referencia; Proyectos de Investigación; Medición de Riesgo

Palabras clave

Benchmark Dose Modelling; Data selection; Genotoxic carcinogen; Margin of Exposure; Tumour relevance; Uncertainty assessment

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Carcinógenos / Incertidumbre Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Food Chem Toxicol Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google