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De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
Zhao, Yao; Farrer, Nicola J; Li, Huilin; Butler, Jennifer S; McQuitty, Ruth J; Habtemariam, Abraha; Wang, Fuyi; Sadler, Peter J.
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  • Zhao Y; Department of Chemistry, University of Warwick, Coventry CV4 7AL (United Kingdom); Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
Angew Chem Int Ed Engl ; 52(51): 13633-7, 2013 Dec 16.
Article en En | MEDLINE | ID: mdl-24167018
Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N3 )2 (OH)2 (MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Guanina Idioma: En Revista: Angew Chem Int Ed Engl Año: 2013 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Platino (Metal) / Guanina Idioma: En Revista: Angew Chem Int Ed Engl Año: 2013 Tipo del documento: Article Pais de publicación: Alemania