The presence of voltage-gated sodium, potassium and chloride channels in rat cultured astrocytes.
Proc R Soc Lond B Biol Sci
; 225(1240): 299-313, 1985 Sep 23.
Article
en En
| MEDLINE
| ID: mdl-2414778
Patch-clamp recording from the plasmalemma of rat cultured astrocytes reveals the presence of both voltage-dependent sodium and voltage-dependent potassium conductances. These conductances are similar but not identical to the corresponding conductances in the axolemma. Whereas the h infinity relation of the sodium channels has the same voltage dependence as in the nodal axolemma, the peak current-voltage relation is shifted by about 30 mV along the voltage axis in the depolarizing direction. It is speculated that the glial cells synthesize sodium and potassium channels for later insertion into the axolemma of neighbouring axons. The astrocytes also express a plasmalemmal voltage-dependent anion conductance that is turned on at about -40 mV (that is, near the resting potential of the cultured astrocytes). The channels involved are large enough to be just permeable to glutamate but not to ascorbate. It is suggested that the conductance of this channel for chloride plays a physiological role in the spatial buffering of potassium by glial cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Astrocitos
/
Canales Iónicos
Límite:
Animals
Idioma:
En
Revista:
Proc R Soc Lond B Biol Sci
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Reino Unido