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Characterization of W-Beijing isolates of Mycobacterium tuberculosis from the Western Cape.
Shanley, Crystal A; Streicher, Elizma M; Warren, Robin M; Victor, Thomas C; Orme, Ian M.
Afiliación
  • Shanley CA; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA. Electronic address: crystal.shanley@colostate.edu.
Vaccine ; 31(50): 5934-9, 2013 Dec 05.
Article en En | MEDLINE | ID: mdl-24144471
The purpose of this simple study was to characterize a panel of clinical isolates of Mycobacterium tuberculosis obtained from the Western Cape region of South Africa where new clinical vaccine trials are beginning, in the low dose aerosol guinea pig infection model. Most of the strains tested grew well in the lungs and other organs of these animals, and in most cases gave rise to moderate to very severe lung damage. We further observed that the current BCG vaccine was highly protective against two randomly selected strains, giving rise to significantly prolonged survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Mycobacterium tuberculosis Límite: Animals / Female / Humans País/Región como asunto: Africa Idioma: En Revista: Vaccine Año: 2013 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Mycobacterium tuberculosis Límite: Animals / Female / Humans País/Región como asunto: Africa Idioma: En Revista: Vaccine Año: 2013 Tipo del documento: Article Pais de publicación: Países Bajos