Your browser doesn't support javascript.
loading
Erythropoietin in amniotic fluid as a potential marker in distinction between growth restricted and constitutionally small fetuses.
Mikovic, Zeljko; Mandic, Vesna; Parovic, Vladimir; Bogavac, Mirjana; Simin, Natasa.
Afiliación
  • Mikovic Z; Department of High-risk Pregnancies, University Clinic for Gynecology and Obstetrics "Narodni front", Medical School, University of Belgrade , Belgrade , Serbia .
J Matern Fetal Neonatal Med ; 27(11): 1134-7, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24144060
OBJECTIVE: To determine if there is any difference in amniotic fluid erythropoietin (EPO) concentration between fetuses small for gestational age (SGA) and appropriate for gestational age (AGA), and between the constitutionally small (CSF) and growth-restricted (GRF) fetuses. METHODS: EPO concentrations in the amniotic fluid samples were determined by EpoELISA test in 38 pregnancies with SGA and 15 pregnancies with AGA fetuses. In the SGA group we measured Ponderal index (PI) and skin-fold thickness (SFT). If PI and/or SFT were below 10th percentile the neonate was GRF. If both PI and SFT were above 10th percentile the neonate was CSF. RESULTS: Higher levels of EPO were detected in the SGA in comparison to the AGA fetuses (p < 0.01). EPO concentration was higher in GRF compared to CSF (p < 0.05). The EPO cut-off level between SGA and AGA was 6.81 IU/L (sensitivity 92.3%; specificity 73.3%), and between GRF and CSF was 9.8 IU/L (sensitivity 81%; specificity 80%). CONCLUSION: The preliminary results of this study suggest that amniotic fluid erythropoietin concentration is elevated in growth-restricted fetuses and could potentially be used for distinction between growth restricted and constitutionally small fetuses. Confirmation of these results on a larger group of pregnant women is needed.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico Prenatal / Recién Nacido Pequeño para la Edad Gestacional / Biomarcadores / Eritropoyetina / Retardo del Crecimiento Fetal / Líquido Amniótico Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico Prenatal / Recién Nacido Pequeño para la Edad Gestacional / Biomarcadores / Eritropoyetina / Retardo del Crecimiento Fetal / Líquido Amniótico Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido