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Antibacterial effects of curcumin: An in vitro minimum inhibitory concentration study.
Gunes, Hayati; Gulen, Dumrul; Mutlu, Reyhan; Gumus, Abdullah; Tas, Tekin; Topkaya, Aynur Eren.
Afiliación
  • Gunes H; Department of Medical Microbiology, Medical Faculty, Namik Kemal University, Tekirdag, Turkey dr_hgunes@yahoo.com.
  • Gulen D; Department of Medical Microbiology, Medical Faculty, Namik Kemal University, Tekirdag, Turkey.
  • Mutlu R; Department of Medical Microbiology, Medical Faculty, Namik Kemal University, Tekirdag, Turkey.
  • Gumus A; Department of Medical Microbiology, Medical Faculty, Namik Kemal University, Tekirdag, Turkey.
  • Tas T; Department of Medical Microbiology, Medical Faculty, Abant Izzet Baysal University, Bolu, Turkey.
  • Topkaya AE; Department of Medical Microbiology, Medical Faculty, Namik Kemal University, Tekirdag, Turkey.
Toxicol Ind Health ; 32(2): 246-50, 2016 Feb.
Article en En | MEDLINE | ID: mdl-24097361
AIM: To evaluate the antibacterial effect of curcumin with the minimum inhibitory concentration (MIC) method in standard bacterial strains. METHODS: The in vitro antibacterial activity of curcumin was evaluated against methicillin-sensitive Staphylococcus aureus (MSSA) (ATCC 29213), methicillin-resistant Staphylococcus aureus (MRSA) (ATCC 43300), Enterococcus faecalis (ATCC 29212), Bacillus subtilis (ATCC 6633), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922) and Klebsiella pneumoniae (ATCC 700603) using the macrodilution broth susceptibility test method. After incubation in tubes, the antibacterial activity of curcumin was detected by a lack of turbidity, which indicated the inhibition of bacterial growth. The concentration in the tube with the highest dilution showing no turbidity was defined as the MIC. RESULTS: The curcumin MIC values were 175 µg/ml, 129 µg/ml, 219 µg/ml, 217 µg/ml, 163 µg/ml, 293 µg/ml and 216 µg/ml against P. aeruginosa, B. subtilis, MSSA, MRSA, E. coli, E. faecalis and K. Pneumonia, respectively. CONCLUSION: This study revealed antibacterial effects of curcumin against standard bacterial strains in high concentrations. Animal experiments have demonstrated that curcumin applied at high doses has strong antibacterial activity. There is a need for further in vivo studies to shed light on antibacterial effects of curcumin with high concentrations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Curcumina / Antibacterianos Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Curcumina / Antibacterianos Idioma: En Revista: Toxicol Ind Health Asunto de la revista: MEDICINA OCUPACIONAL / TOXICOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido