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Neural tube defects, folate, and immune modulation.
Denny, Kerina J; Jeanes, Angela; Fathe, Kristin; Finnell, Richard H; Taylor, Stephen M; Woodruff, Trent M.
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  • Denny KJ; School of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, Australia.
  • Jeanes A; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia.
  • Fathe K; School of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, Australia.
  • Finnell RH; Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas, Austin, Texas.
  • Taylor SM; Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas, Austin, Texas.
  • Woodruff TM; School of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, Australia.
Birth Defects Res A Clin Mol Teratol ; 97(9): 602-609, 2013 Sep.
Article en En | MEDLINE | ID: mdl-24078477
Periconceptional supplementation with folic acid has led to a significant worldwide reduction in the incidence of neural tube defects (NTDs). However, despite increasing awareness of the benefits of folic acid supplementation and the implementation of food fortification programs in many countries, NTDs continue to be a leading cause of perinatal morbidity and mortality worldwide. Furthermore, there exists a significant subgroup of women who appear to be resistant to the protective effects of folic acid supplementation. The following review addresses emerging clinical and experimental evidence for a role of the immune system in the etiopathogenesis of NTDs, with the aim of developing novel preventative strategies to further reduce the incidence of NTD-affected pregnancies. In particular, recent studies demonstrating novel roles and interactions between innate immune factors such as the complement cascade, neurulation, and folate metabolism are explored.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embarazo en Diabéticas / Tetrahidrofolatos / Neurulación / Receptores de Folato Anclados a GPI / Factores Inmunológicos / Defectos del Tubo Neural Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Birth Defects Res A Clin Mol Teratol Año: 2013 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Embarazo en Diabéticas / Tetrahidrofolatos / Neurulación / Receptores de Folato Anclados a GPI / Factores Inmunológicos / Defectos del Tubo Neural Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Birth Defects Res A Clin Mol Teratol Año: 2013 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos