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Protease-activated receptor-2 deficient mice have reduced house dust mite-evoked allergic lung inflammation.
de Boer, J Daan; Van't Veer, Cornelis; Stroo, Ingrid; van der Meer, Anne J; de Vos, Alex F; van der Zee, Jaring S; Roelofs, Joris J T H; van der Poll, Tom.
Afiliación
  • de Boer JD; Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands j.d.deboer@amc.uva.nl.
  • Van't Veer C; Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands.
  • Stroo I; Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands Department of Immunopathology, Sanquin, Amsterdam, the Netherlands.
  • van der Meer AJ; Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands.
  • de Vos AF; Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands.
  • van der Zee JS; Department of Pulmonology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.
  • Roelofs JJ; Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • van der Poll T; Academic Medical Center, University of Amsterdam, Center of Infection and Immunity Amsterdam & Center for Experimental and Molecular Medicine, Amsterdam, the Netherlands Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Innate Immun ; 20(6): 618-25, 2014 Aug.
Article en En | MEDLINE | ID: mdl-24048772
Protease-activated receptor-2 (PAR2) is abundantly expressed in the pulmonary compartment. House dust mite (HDM) is a common cause of allergic asthma and contains multiple PAR2 agonistic proteases. The aim of this study was to determine the role of PAR2 in HDM-induced allergic lung inflammation. For this, the extent of allergic lung inflammation was studied in wild type (Wt) and PAR2 knockout (KO) mice after repeated airway exposure to HDM. HDM exposure of Wt mice resulted in a profound influx of eosinophils in bronchoalveolar lavage fluid (BALF) and accumulation of eosinophils in lung tissue, which both were strongly reduced in PAR2 KO mice. PAR2 KO mice demonstrated attenuated lung pathology and protein leak in the bronchoalveolar space, accompanied by lower BALF levels of the anaphylatoxins C3a and C5a. This study reveals, for the first time, an important role for PAR2 in allergic lung inflammation induced by the clinically relevant allergens contained in HDM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Dermatophagoides farinae / Receptor PAR-2 / Alveolitis Alérgica Extrínseca / Pulmón Límite: Animals Idioma: En Revista: Innate Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / BACTERIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Dermatophagoides farinae / Receptor PAR-2 / Alveolitis Alérgica Extrínseca / Pulmón Límite: Animals Idioma: En Revista: Innate Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / BACTERIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos