Transgenic Rat Models of Huntington's Disease.

Carreira, João Casaca; Jahanshahi, Ali; Zeef, Dagmar; Kocabicak, Ersoy; Vlamings, Rinske; von Hörsten, Stephan; Temel, Yasin

Carreira, João Casaca; Jahanshahi, Ali; Zeef, Dagmar; Kocabicak, Ersoy; Vlamings, Rinske; von Hörsten, Stephan; Temel, Yasin.

Afiliación

Carreira JC; Departments of Neuroscience and Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Curr Top Behav Neurosci ; 22: 135-47, 2015.

Article en En | MEDLINE | ID: mdl-24013873

RESUMEN

Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.

Asunto(s)

Modelos Animales de Enfermedad; Enfermedad de Huntington/patología; Enfermedad de Huntington/fisiopatología; Animales; Ratas; Ratas Transgénicas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Huntington / Modelos Animales de Enfermedad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Curr Top Behav Neurosci Asunto de la revista: CIENCIAS DO COMPORTAMENTO / NEUROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania

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