[Protein components of innate immunity in protection from pathogenic invasion (literature review)].
Zh Mikrobiol Epidemiol Immunobiol
; (3): 111-7, 2013.
Article
en Ru
| MEDLINE
| ID: mdl-24000604
System of innate immunity is a set of effector molecules and cells counteracting invasion of pathogens and their products. Alpha-2-macroglobulin (a2-MG) and lactoferrin (LF) play a significant role in primary protection of organism. A wide spectrum of transport and regulatory functions, high affinity to endocytosis receptor as well as structural features of these proteins allow them not only to effectively protect the organism during direct contact with pathogen but also to have an immunomodulatory impact on immunocompetent cells of adaptive immunity. However despite a common receptor and a number of ligands, mechanisms of realization of protective functions ofa2-MG and LF differ significantly. The aim of this review is to systemize knowledge on means and mechanisms of protection of a 2-MG and LF against invasion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
Infecciones Bacterianas
/
Virus
/
Virosis
/
Alfa-Macroglobulinas
/
Inmunidad Innata
/
Lactoferrina
Límite:
Humans
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Rusia