Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7.
J Immunol
; 191(6): 3393-9, 2013 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-23956435
Viral infection causes host cells to produce type I IFNs, which play a critical role in viral clearance. IFN regulatory factor (IRF) 7 is the master regulator of type I IFN-dependent immune responses. In this article, we report that N-Myc and STATs interactor (Nmi), a Sendai virus-inducible protein, interacted with IRF7 and inhibited virus-triggered type I IFN production. The overexpression of Nmi inhibited the Sendai virus-triggered induction of type I IFNs, whereas the knockdown of Nmi promoted IFN production. Furthermore, the enhanced production of IFNs resulting from Nmi knockdown was sufficient to protect cells from infection by vesicular stomatitis virus. In addition, Nmi was found to promote the K48-linked ubiquitination of IRF7 and the proteasome-dependent degradation of this protein. Finally, an impairment of antiviral responses is also detectable in Nmi-transgenic mice. These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Respirovirus
/
Interferón Tipo I
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Péptidos y Proteínas de Señalización Intracelular
/
Factor 7 Regulador del Interferón
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Immunol
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Estados Unidos