Cinesinas/antagonistas & inhibidores; Cinesinas/metabolismo; Terapia Molecular Dirigida/métodos; Animales; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Humanos; Cinesinas/genética; Mitosis/efectos de los fármacos; Mitosis/genética; Filogenia; Transducción de Señal/genética; Transducción de Señal/fisiología; Huso Acromático/efectos de los fármacos; Huso Acromático/metabolismo

ADP; AMPPNP; AP1; ATP; ATP hydrolysis; Allosteric inhibition; CDK1; DMSO; DNA; Eg5; GFP; GTP; ICL; KHC; KSP; Kinesin; L5; MT; Mitosis; NCBI; NER; NTP; NTPases; National Center for Biotechnology Information; P loop; P(i); PDB; Protein DataBank; RNAi; RefSeq; Reference Sequence; S-trityl-l-cysteine; STC; Traf4; XPF; Xeroderma pigmentosum group F; activator protein 1; adenosine diphosphate; adenosine-5'-(ß,γ-imido)triphosphate; adenosine-5'-triphosphate; cryo-EM; cryo-electron microscopy; cyclin-dependent kinase 1; deoxyribonucleic acid; dimethyl sulfoxide; double stranded ribonucleic acid interference; dsRNAi; green fluorescent protein; guanosine-5'-triphosphate; inorganic phosphate; interstrand DNA cross-linking; kDa; kilodalton; kinesin heavy chain; kinesin spindle protein; loop 5; microtubule; nucleotide excision repair; nucleotide triphosphatases; nucleotide triphosphate; pN; phosphate-binding loop; piconewton; ribonucleic acid interference; siRNA; small interfering ribonucleic acid; tumor necrosis factor receptor associated factor 4