Zinc in traumatic brain injury: from neuroprotection to neurotoxicity.
Curr Opin Clin Nutr Metab Care
; 16(6): 708-11, 2013 Nov.
Article
en En
| MEDLINE
| ID: mdl-23945221
PURPOSE OF REVIEW: In light of the recent recognition that even mild forms of traumatic brain injury (TBI) can lead to long-term cognitive and behavioral deficits, this review examines recent data on the neuroprotective and neurotoxic roles of zinc after brain injury. RECENT FINDINGS: Data show that treatment using dietary and parenteral zinc supplementation can reduce TBI-associated depression and improve cognitive function, specifically spatial learning and memory. However, excessive release of free zinc, particularly in the hippocampus associated with acute injury, can lead to increases in protein ubiquitination and neuronal death. SUMMARY: This work shows the need for future research to clarify the potentially contradictory roles of zinc in the hippocampus and define the clinical use of zinc as a treatment following brain injury in humans. This is particularly important given the finding that zinc may reduce TBI-associated depression, a common and difficult outcome to treat in all forms of TBI.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zinc
/
Lesiones Encefálicas
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Fármacos Neuroprotectores
/
Suplementos Dietéticos
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Síndromes de Neurotoxicidad
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Clin Nutr Metab Care
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido