Regioselective tandem N-alkylation/C-acylation of ß,γ-alkynyl α-imino esters.
Org Lett
; 15(16): 4206-9, 2013 Aug 16.
Article
en En
| MEDLINE
| ID: mdl-23909700
A new synthesis of α-quaternary alkynyl amino esters and allenoates was developed utilizing umpolung N-addition to ß,γ-alkynyl α-imino esters followed by regioselective acylation. The reaction exhibits broad substrate generality and unique regioselectivity. Moreover, synthesis of α-quaternary alkynyl amino esters was also carried out via oxidation of the intermediary enolate followed by alkylation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Iminoácidos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos