Cerebellar degeneration induced by acetyl-ethyl-tetramethyl-tetralin(AETT).
Acta Neuropathol
; 80(2): 129-37, 1990.
Article
en En
| MEDLINE
| ID: mdl-2389677
The neurotoxicity of acetyl-ethyl-tetramethyl-tetralin (AETT) was investigated following its percutaneous administration to rats. Animals exposed to a high-dose of AETT developed a gait abnormality that progressed to severe ataxia. Microscopic examinations revealed remarkable cerebellar changes in addition to a widespread accumulation of ceroid-like pigmentation in the neuronal cytoplasm. The cerebellar changes, especially in the vermis and intermediate part, were characterized by selective degeneration and depopulation of Purkinje cells, and a spongy state of the cerebellar white matter, which was formed in splits in the intraperiod lines within the myelin sheath. In contrast, there were only negligible changes of granule cells and other neuronal elements. Accumulation of ceroid-like pigments and selective damage to the Purkinje cells seen in the present study together provide a basis for understanding the pathogenesis of AETT intoxication and distinguish it from other experimentally induced conditions. Thus, high-dosage AETT intoxicated rats may constitute a new experimental model of cerebellar degeneration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tetrahidronaftalenos
/
Cerebelo
/
Naftalenos
/
Neurotoxinas
Límite:
Animals
Idioma:
En
Revista:
Acta Neuropathol
Año:
1990
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Alemania