Intraductal acidosis in acute biliary pancreatitis.
Pancreatology
; 13(4): 333-5, 2013.
Article
en En
| MEDLINE
| ID: mdl-23890129
Acute pancreatitis recently became the most common cause for hospitalization among gastrointestinal diseases. There is no specific therapy against the disease due to insufficient understanding of pathogenesis. Animal and in vitro models indicated that reduced pancreatic ductal bicarbonate secretion and consequent intraductal acidosis is an early event in acute pancreatitis, but human data are lacking. Therefore, our aim was to determine the luminal pH in the main pancreatic duct during acute pancreatitis in humans. Intraductal pH was measured in patients with acute biliary pancreatitis (n = 6) during endoscopic retrograde cholangio-pancreatography. Patients with common bile stones without pancreatitis (n = 5) and a patient with an adenoma of the papilla of Vater served as controls. The luminal pH was significantly lower in the group of acute biliary pancreatitis vs. controls (6.97 ± 0.13 vs. 7.79 ± 0.20). Our brief report shows for the first time that there is marked intraductal acidosis in acute biliary pancreatitis, which seems to worsen with time. Further clinical trials are needed to determine the exact roles of reduced intraductal pH in ABP.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conductos Pancreáticos
/
Pancreatitis
/
Acidosis
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Pancreatology
Asunto de la revista:
ENDOCRINOLOGIA
/
GASTROENTEROLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Hungria
Pais de publicación:
Suiza