A case of acute promyelocytic leukemia with morphologic multilineage dysplastic changes.
Hematol Rep
; 5(1): 18-20, 2013 Jan 25.
Article
en En
| MEDLINE
| ID: mdl-23888241
Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS). The patient, a 77-year-old Japanese male, was diagnosed as having pancytopenia with hematologic morphological abnormalities comprising micro - megakaryocytes, neutrophils with hypo-granulation and negative peroxidase activity, and erythroblasts containing nuclei with abnormalities such as karyorrhexis. Although there is one report of a case of transformation of de novo MDS into APL and several reports of cases of therapy-related MDS transformed into APL, our patient had no history of cytopenia or of either chemo or radiation therapy. Our case can thus be considered to constitute a rare case of APL with dysplastic morphology.
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01-internacional
Base de datos:
MEDLINE
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En
Revista:
Hematol Rep
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Suiza