Amiodarona/farmacocinética; Citrus/química; Frutas/química; Interacciones de Hierba-Droga; Extractos Vegetales/farmacología; Administración Oral; Animales; Área Bajo la Curva; Peso Corporal; Relación Dosis-Respuesta a Droga; Semivida; Masculino; Ratas; Ratas Wistar

AM; AUC; AUC from time zero to infinite; AUC from time zero to the last sampling time; AUC(0−)(t); AUC(0−∞); Amiodarone; C(last); C(max); CYP; Citrus aurantium; FDA; Food and Drug Administration; Herb­drug interaction; LOQ; MDEA; MRT; P-glycoprotein; P-gp; Pharmacokinetics; Rats; SD; UV; amiodarone; apparent terminal elimination half-life; apparent terminal rate constant; area under the concentration-time curve; cytochrome P450; i.p.; intraperitoneal; k(el); last quantifiable concentration; limit of quantification; mean residence time; mono-N-desethylamiodarone; peak concentration; standard deviation; t(1/2el); t(max); time to reach C(max); ultraviolet detection