Consolidation trend design based on Young's modulus of clarithromycin single crystals.
Int J Pharm
; 454(1): 324-32, 2013 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-23872226
The key aim of this study was to determine single mechanical properties of clarithromycin polymorphic forms in order to select some of them as more suitable for the tableting process. For this purpose, AFM single-point nanoindentation was used. The Young's moduli of clarithromycin polymorphs were substantially different, which was consistent with the structural variations in their packing motifs. The presence of the adjacent layers, which can easily slide over each other due to the low energy barrier (the lowest Young's modulus was 0.25 GPa) resulted in better bulk compressibility (the highest Heckel coefficient) of clarithromycin Form I. We also addressed the importance of tip geometry screening because the stress during the force mode often results in tip apex fracture. Even the initial manufacture of the diamond-coated tips can result in defects such as double-apex tips.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Claritromicina
Idioma:
En
Revista:
Int J Pharm
Año:
2013
Tipo del documento:
Article
País de afiliación:
Eslovenia
Pais de publicación:
Países Bajos