Your browser doesn't support javascript.
loading
Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-κB-mediated antiapoptotic pathway.
Huang, C-K; Yang, C-Y; Jeng, Y-M; Chen, C-L; Wu, H-H; Chang, Y-C; Ma, C; Kuo, W-H; Chang, K-J; Shew, J-Y; Lee, W-H.
Afiliación
  • Huang CK; 1] Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Yang CY; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Jeng YM; Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
  • Chen CL; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Wu HH; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Chang YC; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Ma C; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Kuo WH; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
  • Chang KJ; 1] Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan [2] Cheng Chin General Hospital, Taichung, Taiwan.
  • Shew JY; 1] Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Lee WH; 1] Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan [2] Genomics Research Center, Academia Sinica, Taipei, Taiwan [3] Department of Biological Chemistry, University of California, Irvine, CA, USA.
Oncogene ; 33(23): 2968-77, 2014 Jun 05.
Article en En | MEDLINE | ID: mdl-23851503
Gain of function of membrane receptor was a good strategy exploited by cancer cells to benefit own growth and survival. Overexpression of HER2 has been found to serve as a target for developing trastuzumab to treat 20-25% of breast cancer. However, little or none of the other membrane receptor was found to be useful as a potential target for breast cancer treatment since then. Here, we showed that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promoted tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. External signal transmitted through IL-17RB activated nuclear factor-κB to upregulate antiapoptotic factor Bcl-2 and induced etoposide resistance. Elevated expression of IL-17RB had a stronger correlation with poor prognosis than HER2 in breast cancer patients. Interestingly, breast cancer patients with high expression of IL-17RB and HER2 had the shortest survival rate. Depletion of IL-17RB in trastuzumab-resistant breast cancer cells significantly reduced their tumorigenic activity, suggesting that IL-17RB and HER2 have an independent role in breast carcinogenesis. Furthermore, treatment with antibodies specifically against IL-17RB or IL-17B effectively attenuated tumorigenicity of breast cancer cells. These results suggest that the amplified IL-17RB/IL-17B signaling pathways may serve as a therapeutic target for developing treatment to manage IL-17RB-associated breast cancer.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / FN-kappa B / Receptores de Interleucina-17 / Carcinogénesis Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / FN-kappa B / Receptores de Interleucina-17 / Carcinogénesis Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido