The expression and immunohistochemical localization of periostin in odontogenic tumors of mixed epithelial/mesenchymal origin.
Oral Surg Oral Med Oral Pathol Oral Radiol
; 116(2): 214-20, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23849375
OBJECTIVE: The object of this study was to determine the expression and localization of periostin in the major mixed odontogenic tumors and to correlate any differential staining of the mesenchymal components to the interrelationship of these tumors. STUDY DESIGN: Five ameloblastic fibromas, 8 ameloblastic fibro-odontomas and 10 odontomas were assessed immunohistochemically for periostin staining. Because mesenchymal tissues were consistently present in all studied cases, these tissues were selected for statistical analysis of differential periostin staining. RESULTS: Periostin was variably localized to the mesenchymal component of the tumors as well as to preameloblasts and ameloblasts. Analysis of the mesenchymal staining intensity was statistically significantly different between ameloblastic fibro-odontomas and odontomas (P < .001; Dunn multiple comparisons test). CONCLUSIONS: Our results document periostin staining in human mixed odontogenic tumors. Statistical analysis of differential stromal staining supports the concept that the ameloblastic fibroma is a histogenetically distinct neoplasm as compared to ameloblastic fibro-odontoma and odontoma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tumores Odontogénicos
/
Moléculas de Adhesión Celular
Límite:
Adolescent
/
Adult
/
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos