[Effects of natural and synthetic PGF2 alpha preparations on the uterine contractility of cattle]. / Auswirkungen natürlicher und synthetischer PGF2 alpha-Präparate auf die Uteruskontraktilität des Rindes.
Berl Munch Tierarztl Wochenschr
; 103(6): 198-202, 1990 Jun 01.
Article
en De
| MEDLINE
| ID: mdl-2383227
The effects of luteolytic doses of PGF2 alpha (25 mg Dinoprost) and its synthetic analogues Cloprostenol (500 micrograms), Luprostiol (15 mg) and Tiaprost (525 micrograms) on bovine myometrial activity were investigated using a miniature pressure transducer placed in one uterine horn. The compounds were administered intravenously to 4 lactating cyclic cows at diestrus, proestrus, estrus and metestrus. Intrauterine pressure changes were assessed by computerized planimetry of the pressure tracings 30 minutes before and 60 minutes after treatment. Baseline intrauterine pressure was set at zero and treatment effects were expressed as percent change from an equivalent control period (= 100%). Following administration of Dinoprost there was a significant increase of uterine contractility in diestrus (515%), proestrus (198%) and metestrus (256%), but not in estrus. In comparison to PGF2 alpha the analogues Luprostiol and Tiaprost were less effective (Luprostiol: 195% and 154% in diestrus and proestrus resp., Tiaprost: 215% during diestrus), while Cloprostenol did not cause a significant change of intrauterine pressure in any stage of the estrous cycle. The results indicate that the myotonic effects which F2 alpha-prostaglandins exert on the uterus of cycling cows is affected both by the type of prostaglandin and the stage of the estrous cycle.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiofenos
/
Contracción Uterina
/
Bovinos
/
Dinoprost
/
Luteolíticos
Límite:
Animals
Idioma:
De
Revista:
Berl Munch Tierarztl Wochenschr
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Alemania