Association between the ABCG2 C421A polymorphism and Alzheimer's disease.
Neurosci Lett
; 550: 51-4, 2013 Aug 29.
Article
en En
| MEDLINE
| ID: mdl-23827224
ATP binding cassette subfamily G member 2 (ABCG2) is involved in amyloid-ß transport and was found to be significantly up-regulated in Alzheimer's disease (AD) brain. A functional polymorphism of the ABCG2 gene (C421A; rs2231142) was genotyped in a sample of 299 Hungarian late-onset AD patients and 259 elderly, non-demented controls to investigate for the first time its association with AD, either alone or in combination with apolipoprotein E (APOE) É2/É3/É4 polymorphism. A significantly increased susceptibility to AD (OR=1.741, 95% CI: 1.075-2.819, p=0.024) associated with ABCG2 C/C genotype was found when compared with the variant allele containing genotypes (CA and AA) as the reference category. Logistic regression analysis revealed a significant interaction effect between the ABCG2 C/C genotype and APOE É4 allele on AD risk (p=0.003). It seems that the potential modest risk effect of the ABCG2 C/C genotype on AD risk is more pronounced in combination with the APOE É4 allele. Further independent replications of our findings are required.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transportadoras de Casetes de Unión a ATP
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Enfermedad de Alzheimer
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Proteínas de Neoplasias
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Neurosci Lett
Año:
2013
Tipo del documento:
Article
País de afiliación:
Hungria
Pais de publicación:
Irlanda