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Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies.
Oyer, J A; Huang, X; Zheng, Y; Shim, J; Ezponda, T; Carpenter, Z; Allegretta, M; Okot-Kotber, C I; Patel, J P; Melnick, A; Levine, R L; Ferrando, A; Mackerell, A D; Kelleher, N L; Licht, J D; Popovic, R.
Afiliación
  • Oyer JA; Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Huang X; 1] Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA [2] Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes, Northwestern University, Evanston, IL, USA.
  • Zheng Y; Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes, Northwestern University, Evanston, IL, USA.
  • Shim J; University of Maryland School of Pharmacy, University of Maryland Greenebaum Cancer Center, Baltimore, MD, USA.
  • Ezponda T; Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Carpenter Z; Department of Pathology, Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY, USA.
  • Allegretta M; Department of Pathology, Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY, USA.
  • Okot-Kotber CI; Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Patel JP; Human Oncology and Pathogenesis Program, Leukemia Service, Department of medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Melnick A; Deparment of Medicine, Division of Hematology/oncology, Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.
  • Levine RL; Human Oncology and Pathogenesis Program, Leukemia Service, Department of medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • Ferrando A; Department of Pathology, Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY, USA.
  • Mackerell AD; University of Maryland School of Pharmacy, University of Maryland Greenebaum Cancer Center, Baltimore, MD, USA.
  • Kelleher NL; Department of Chemistry and Molecular Biosciences, Chemistry of Life Processes, Northwestern University, Evanston, IL, USA.
  • Licht JD; Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Popovic R; Division of Hematology/Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Leukemia ; 28(1): 198-201, 2014 Jan.
Article en En | MEDLINE | ID: mdl-23823660
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Cromatina / N-Metiltransferasa de Histona-Lisina / Mutación Puntual / Metilación de ADN / Linfoma Límite: Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Represoras / Cromatina / N-Metiltransferasa de Histona-Lisina / Mutación Puntual / Metilación de ADN / Linfoma Límite: Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido