Photochemical reactions of quindoxin, olaquindox, carbadox and cyadox with protein, indicating photoallergic properties.
Toxicology
; 63(1): 85-95, 1990 Jul.
Article
en En
| MEDLINE
| ID: mdl-2382272
Quindoxin (quinoxaline-1,4-dioxide), a former 'growth promoter' used in animal husbandry, has been taken from the market because of its photoallergic properties. Nowadays its derivatives olaquindox, carbadox and cyadox are frequently applied for the same purpose. Recent reports show that olaquindox too, can induce photoallergic skin reactions in stockmen. From the present investigation it appeared that all compounds mentioned, form a reactive oxaziridine upon exposure to light, just like many other imino-N-oxides. Photoreactivity with protein, which is considered as an important condition for a compound to be a potential photoallergen, was also studied. Quindoxin and olaquindox proved to meet this condition, as was expected. But carbadox and cyadox also react and were shown to be even more reactive towards human serum albumin.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos por Fotosensibilidad
/
Quinoxalinas
/
Carbadox
/
Proteínas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Toxicology
Año:
1990
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Irlanda