STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.

Dorritie, K A; McCubrey, J A; Johnson, D E

Dorritie, K A; McCubrey, J A; Johnson, D E.

Afiliación

Dorritie KA; Department of Medicine, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
McCubrey JA; Department of Microbiology and Immunology, School of Medicine, East Carolina University, Greenville, NC, USA.
Johnson DE; Department of Pharmacology and Chemical Biology, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.

Leukemia ; 28(2): 248-57, 2014 Feb.

Article en En | MEDLINE | ID: mdl-23797472

RESUMEN

Signal transducer and activator of transcription (STAT) proteins comprise a family of transcription factors that are activated by cytokines, hormones and growth factors. The activation of STAT proteins plays a key role in the production of mature hematopoietic cells via effects on cellular proliferation, survival and lineage-specific differentiation. Emerging evidence also demonstrates frequent, constitutive activation of STATs in primary leukemia specimens. Moreover, roles for STATs in promoting leukemia development have been delineated in numerous preclinical studies. This review summarizes our current understanding of STAT protein involvement in normal hematopoiesis and leukemogenesis, as well as recent advances in the development and testing of novel STAT inhibitors.

Asunto(s)

Transformación Celular Neoplásica/metabolismo; Hematopoyesis; Leucemia/metabolismo; Factores de Transcripción STAT/metabolismo; Empalme Alternativo; Animales; Transformación Celular Neoplásica/genética; Hematopoyesis/genética; Humanos; Leucemia/tratamiento farmacológico; Leucemia/genética; Terapia Molecular Dirigida; Factores de Transcripción STAT/antagonistas & inhibidores; Factores de Transcripción STAT/genética; Transducción de Señal/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia / Transformación Celular Neoplásica / Factores de Transcripción STAT / Hematopoyesis Límite: Animals / Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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