Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.

Horrocks, P; Pickard, M R; Parekh, H H; Patel, S P; Pathak, Ravindra B

Horrocks, P; Pickard, M R; Parekh, H H; Patel, S P; Pathak, Ravindra B.

Afiliación

Horrocks P; Institute for Sciences and Technology in Medicine, Keele University, Keele, Staffordshire, ST5 5BG, UK.

Org Biomol Chem ; 11(29): 4891-8, 2013 Aug 07.

Article en En | MEDLINE | ID: mdl-23779132

RESUMEN

3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.

Asunto(s)

Antifúngicos/farmacología; Aspergillus/efectos de los fármacos; Candida/efectos de los fármacos; Cryptococcus neoformans/efectos de los fármacos; Mycobacterium tuberculosis/efectos de los fármacos; Pirazoles/farmacología; Antifúngicos/síntesis química; Antifúngicos/química; Relación Dosis-Respuesta a Droga; Pruebas de Sensibilidad Microbiana; Estructura Molecular; Pirazoles/síntesis química; Pirazoles/química; Relación Estructura-Actividad

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Aspergillus / Candida / Cryptococcus neoformans / Mycobacterium tuberculosis / Antifúngicos Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2013 Tipo del documento: Article Pais de publicación: Reino Unido

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