Antiestrogens suppress effects of transforming growth factor-ß in breast cancer cells via the signaling axis estrogen receptor-α and Y-box Binding Protein-1.
Anticancer Res
; 33(6): 2473-80, 2013 Jun.
Article
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| MEDLINE
| ID: mdl-23749898
BACKGROUND: Multifunctional Y-box Binding Protein-1 (YB1) is correlated with a poor outcome in breast cancer. We found YB1 expression to be regulated by antiestrogens commonly used in the hormonal therapy of breast cancer and known as activators of Transforming Growth Factor-ß (TGFß). Thus, a putative influence of YB1 on TGFß signaling should be investigated. MATERIALS AND METHODS: The effect of YB1 on TGFß signaling was monitored by expression analysis and reporter gene assays in breast cancer cells overexpressing YB1 and treated with antiestrogens. RESULTS: Antiestrogen-mediated inhibition of estrogen receptor-α led to a suppression of YB1 protein synthesis. On the other hand, YB1 was found to be an enhancer of TGFß signaling. CONCLUSION: High levels of YB1 expression lead to a stimulation of TGFß pathways, thereby counteracting antihormonal breast cancer therapy and representing a putative resistance mechanism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Factor de Crecimiento Transformador beta
/
Receptor alfa de Estrógeno
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Antagonistas de Estrógenos
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Proteína 1 de Unión a la Caja Y
Límite:
Female
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Humans
Idioma:
En
Revista:
Anticancer Res
Año:
2013
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Grecia