Caspr interaction with Amyloid Precursor Protein reduces amyloid-ß generation in vitro.
Neurosci Lett
; 548: 255-60, 2013 Aug 26.
Article
en En
| MEDLINE
| ID: mdl-23748076
Contactin associated protein (Caspr), an adhesion molecule, plays roles in formation of paranodal junctions in myelinated axons, neurite outgrowth, synaptic plasticity in nervous system. Here we have shown a novel function of Caspr in pathogenesis of Alzheimer's disease (AD). Caspr distributes around amyloid plaques in APP/PS1 mice. Levels of Caspr increase in the cerebral cortex of 7-month-old APP/PS1 mice comparing to wild-type littermates. Caspr decreased protein levels of APP in both HEK-293 cells stably transfected with Indiana mutant APP (V717F; HEK-APP) and CHO cells which express endogenous APP, while it did not alter mRNA levels of APP. Furthermore, Caspr co-localizes and interacts with APP. Amyloid-ß (Aß) 40 and Aß42 generation were also reduced in HEK-APP cells by Caspr overexpression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Encéfalo
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Moléculas de Adhesión Celular Neuronal
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Péptidos beta-Amiloides
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Enfermedad de Alzheimer
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2013
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Irlanda