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Economic evaluation of 3-drug antiretroviral regimens for the prevention of mother-to-child HIV transmission in Thailand.
Werayingyong, Pitsaphun; Phanuphak, Nittaya; Chokephaibulkit, Kulkunya; Tantivess, Sripen; Kullert, Nareeluk; Tosanguan, Kakanang; Butchon, Rukmanee; Voramongkol, Nipunporn; Boonsuk, Sarawut; Pilasant, Songyot; Kulpeng, Wantanee; Teerawattananon, Yot.
Afiliación
  • Werayingyong P; Health Intervention and Technology Assessment Program, Nonthaburi, Thailand pitsaphun.w@hitap.net.
  • Phanuphak N; The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Chokephaibulkit K; Mahidol University, Bangkok, Thailand.
  • Tantivess S; Health Intervention and Technology Assessment Program, Nonthaburi, Thailand.
  • Kullert N; Ministry of Public Health, Nonthaburi, Thailand.
  • Tosanguan K; Health Intervention and Technology Assessment Program, Nonthaburi, Thailand.
  • Butchon R; Health Intervention and Technology Assessment Program, Nonthaburi, Thailand.
  • Voramongkol N; Ministry of Public Health, Nonthaburi, Thailand.
  • Boonsuk S; Benjalak Hospital, Nonthaburi, Thailand.
  • Pilasant S; Health Intervention and Technology Assessment Program, Nonthaburi, Thailand.
  • Kulpeng W; Health Intervention and Technology Assessment Program, Nonthaburi, Thailand.
  • Teerawattananon Y; Health Intervention and Technology Assessment Program, Nonthaburi, Thailand.
Asia Pac J Public Health ; 27(2): NP866-76, 2015 Mar.
Article en En | MEDLINE | ID: mdl-23728769
The current program for prevention of mother-to-child HIV transmission in Thailand recommends a 2-drugs regimen for HIV-infected pregnant women with a CD4 count >200 cells/mm(3). This study assesses the value for money of 3 antiretroviral drugs compared with zidovudine (AZT)+single-dose nevirapine (sd-NVP). A decision tree was constructed to predict costs and outcomes using the governmental perspective for assessing cost-effectiveness of 3-drug regimens: (1) AZT, lamivudine, and efavirenz and (2) AZT, 3TC, and lopinavir/ritonavir, in comparison with the current protocol, AZT+sd-NVP. The 3-drug antiretroviral regimens yield lower costs and better health outcomes compared with AZT+sd-NVP. Although these 3-drug regimens offer higher program costs and health care costs for premature birth, they save money significantly in regard to pediatric HIV treatment and treatment costs for drug resistance in mothers. The 3-drug regimens are cost-saving interventions. The findings from this study were used to support a policy change in the national recommendation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa / Fármacos Anti-VIH Tipo de estudio: Guideline / Health_economic_evaluation / Prognostic_studies Límite: Adult / Female / Humans / Infant / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Asia Pac J Public Health Asunto de la revista: SAUDE PUBLICA Año: 2015 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa / Fármacos Anti-VIH Tipo de estudio: Guideline / Health_economic_evaluation / Prognostic_studies Límite: Adult / Female / Humans / Infant / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Asia Pac J Public Health Asunto de la revista: SAUDE PUBLICA Año: 2015 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: China