Recurrent chromosomal aberrations in peripheral T-cell lymphoma.

Montaldi, A; Chisesi, T; Stracca-Pansa, V; Celli, P; Vespignani, M; Stella, M

Montaldi, A; Chisesi, T; Stracca-Pansa, V; Celli, P; Vespignani, M; Stella, M.

Afiliación

Montaldi A; Service of Immunology, Blood Transfusion, and Human Genetics, Ospedale San Bortolo, Vicenza, Italy.

Cancer Genet Cytogenet ; 48(1): 39-48, 1990 Aug 01.

Article en En | MEDLINE | ID: mdl-2372786

RESUMEN

Histological, immunological, and cytogenetic analysis of the same neoplastic tissues have been performed on seven patients with peripheral T-cell lymphomas (PTCL). Clonal chromosomal abnormalities in five cases are reported. The most common chromosomal aberration, observed in four patients, is a rearrangement of chromosome 14 with a breakpoint in q11.2. Aberrations of chromosome 8 also occurred in four patients, three of whom had an extra 8q. The data indicate that breakpoints of malignant diseases affecting similar cell types might cluster to specific chromosomal regions, which can be helpful in recognition and classification of PTCL.

Asunto(s)

Aberraciones Cromosómicas; Linfoma/genética; Adulto; Anciano; Bandeo Cromosómico; Femenino; Marcadores Genéticos; Humanos; Cariotipificación; Masculino; Persona de Mediana Edad; Linfocitos T

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aberraciones Cromosómicas / Linfoma Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Genet Cytogenet Año: 1990 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

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