Interfacing cellular networks of S. cerevisiae and E. coli: connecting dynamic and genetic information.
BMC Genomics
; 14: 324, 2013 May 11.
Article
en En
| MEDLINE
| ID: mdl-23663484
BACKGROUND: In recent years, various types of cellular networks have penetrated biology and are nowadays used omnipresently for studying eukaryote and prokaryote organisms. Still, the relation and the biological overlap among phenomenological and inferential gene networks, e.g., between the protein interaction network and the gene regulatory network inferred from large-scale transcriptomic data, is largely unexplored. RESULTS: We provide in this study an in-depth analysis of the structural, functional and chromosomal relationship between a protein-protein network, a transcriptional regulatory network and an inferred gene regulatory network, for S. cerevisiae and E. coli. Further, we study global and local aspects of these networks and their biological information overlap by comparing, e.g., the functional co-occurrence of Gene Ontology terms by exploiting the available interaction structure among the genes. CONCLUSIONS: Although the individual networks represent different levels of cellular interactions with global structural and functional dissimilarities, we observe crucial functions of their network interfaces for the assembly of protein complexes, proteolysis, transcription, translation, metabolic and regulatory interactions. Overall, our results shed light on the integrability of these networks and their interfacing biological processes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
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Biología Computacional
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Escherichia coli
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Redes Reguladoras de Genes
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Mapas de Interacción de Proteínas
Tipo de estudio:
Qualitative_research
Idioma:
En
Revista:
BMC Genomics
Asunto de la revista:
GENETICA
Año:
2013
Tipo del documento:
Article
Pais de publicación:
Reino Unido