[The nucleolus of the cell is the site of iron accumulation in the substantia nigra neurons of the human brain].

Sukhorukova, Ye G; Grigoriev, I P; Kolos, Ye A; Korzhenevskiy, D E

Sukhorukova, Ye G; Grigoriev, I P; Kolos, Ye A; Korzhenevskiy, D E.

Afiliación

Sukhorukova YG; RAMS North-Western Branch Institute of Experimental Medicine, St. Petersburg, Russia

Morfologiia ; 142(6): 61-2, 2012.

Article en Ru | MEDLINE | ID: mdl-23659042

RESUMEN

Distribution of iron in the substantia nigra of the human brain (10 men and women aged 27-78 years) was studied using Perls' histochemical method. Iron ions were demonstrated in the nigral neuropil and melanin-containing neurons. For the first time the nuclei of some neurons were found to contain iron accumulations. The intranuclear iron inclusions correspond to the nucleolus according to their sharp outline and sizes. Detection of iron in the neuronal nucleolus may contribute to the understanding of mechanisms of iron neurotoxicity for nigral dopaminergic neurons.

Asunto(s)

Nucléolo Celular/química; Hierro/análisis; Neuronas/química; Sustancia Negra/química; Adulto; Anciano; Femenino; Humanos; Masculino; Persona de Mediana Edad; Neurópilo/química; Sustancia Negra/citología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancia Negra / Nucléolo Celular / Hierro / Neuronas Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Ru Revista: Morfologiia Asunto de la revista: ANATOMIA Año: 2012 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia

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