Your browser doesn't support javascript.
loading
The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.
Barry, G; Briggs, J A; Vanichkina, D P; Poth, E M; Beveridge, N J; Ratnu, V S; Nayler, S P; Nones, K; Hu, J; Bredy, T W; Nakagawa, S; Rigo, F; Taft, R J; Cairns, M J; Blackshaw, S; Wolvetang, E J; Mattick, J S.
Afiliación
  • Barry G; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Briggs JA; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
  • Vanichkina DP; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Poth EM; Department of Neuroscience, Neurology and Ophthalmology, Center for High-Throughput Biology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Beveridge NJ; 1] Schizophrenia Research Institute, Sydney, NSW, Australia [2] The University of Newcastle, Callaghan, NSW, Australia.
  • Ratnu VS; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
  • Nayler SP; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
  • Nones K; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.
  • Hu J; Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Bredy TW; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
  • Nakagawa S; RNA Biology Laboratory, RIKEN Advanced Research Institute, Wako, Saitama, Japan.
  • Rigo F; Isis Pharmaceuticals, Carlsbad, CA, USA.
  • Taft RJ; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  • Cairns MJ; 1] Schizophrenia Research Institute, Sydney, NSW, Australia [2] The University of Newcastle, Callaghan, NSW, Australia.
  • Blackshaw S; Department of Neuroscience, Neurology and Ophthalmology, Center for High-Throughput Biology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Wolvetang EJ; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
  • Mattick JS; 1] Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia [2] Garvan Institute of Medical Research, Sydney, NSW, Australia [3] St Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
Mol Psychiatry ; 19(4): 486-94, 2014 Apr.
Article en En | MEDLINE | ID: mdl-23628989
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the molecular mechanisms responsible are unknown. Additionally, there is limited understanding of the early transcriptomic responses to neuronal activation. Here, we profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically regulated by neuronal activation, including acute downregulation of the lncRNA Gomafu, previously implicated in brain and retinal development. Moreover, we demonstrate that Gomafu binds directly to the splicing factors QKI and SRSF1 (serine/arginine-rich splicing factor 1) and dysregulation of Gomafu leads to alternative splicing patterns that resemble those observed in SZ for the archetypal SZ-associated genes DISC1 and ERBB4. Finally, we show that Gomafu is downregulated in post-mortem cortical gray matter from the superior temporal gyrus in SZ. These results functionally link activity-regulated lncRNAs and alternative splicing in neuronal function and suggest that their dysregulation may contribute to neurological disorders.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Regulación de la Expresión Génica / Empalme Alternativo / ARN Largo no Codificante / Proteínas del Tejido Nervioso / Neuronas Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Regulación de la Expresión Génica / Empalme Alternativo / ARN Largo no Codificante / Proteínas del Tejido Nervioso / Neuronas Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido