Bactericidal activity of lachrymal secretion and complement system in copper deficient bovines.
Biol Trace Elem Res
; 153(1-3): 178-83, 2013 Jun.
Article
en En
| MEDLINE
| ID: mdl-23625728
Copper deficiency in humans and animals has been related to increased susceptibility to infections. Neutrophils are one of the most studied components of the immune response; however, to the best of our knowledge, other defenses of the innate immune system have not been analyzed in copper-deficient animals. Our previous studies in copper-deficient bovines have shown increased susceptibility to infectious keratoconjunctivitis, an ocular disease caused by Moraxella bovis. The objective of this work was to evaluate the bactericidal activity of lachrymal secretion and complement system, two main mechanisms of the innate immune response against M. bovis, in copper-deficient cattle. Our results indicate that copper deficiency has no effect on bactericidal activity of complement system and lachrymal secretion against M. bovis in calves. Other components of local and systemic ocular defense mechanisms that could explain the increased susceptibility to infectious keratoconjunctivitis observed in copper-deficient bovines should be investigated.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas del Sistema Complemento
/
Cobre
/
Aparato Lagrimal
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Biol Trace Elem Res
Año:
2013
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Estados Unidos