[Would D'Arcy Thompson have predicted a topological control of apoptosis?]. / D'Arcy Thompson aurait-il prédit un contrôle topologique de l'apoptose ?
Med Sci (Paris)
; 29(4): 411-5, 2013 Apr.
Article
en Fr
| MEDLINE
| ID: mdl-23621937
The laws that drive morphogenesis remain a major biological question. Today's views emphasize molecular autonomous processes rather than physical and mechanical constraints proposed by d'Arcy Thompson earlier on. In Ciona intestinalis oocyte, follicular cells formed by two distinct sets of geometrically-ordered epithelial monolayers positioned over the egg control apoptosis, implying that physically-predetermined shapes play a role in the control of cell determinism. In follicular cells ideally positioned over the spherical geometry of the egg, a drastic, optimized and polarized inward apoptosis sequence directly results from this positioning, suggesting the existence of some apoptotic master cells which control the destiny of neighboring cells. This concept could shed a new light on the origin of massive apoptosis phases that take place during embryogenesis in vertebrates (e.g., cavitation, inter-digitation). It could also be applied to specific therapeutic strategies to fight cancer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apoptosis
/
Morfogénesis
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
Fr
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia