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MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.
Corr, S C; Palsson-McDermott, E M; Grishina, I; Barry, S P; Aviello, G; Bernard, N J; Casey, P G; Ward, J B J; Keely, S J; Dandekar, S; Fallon, P G; O'Neill, L A J.
Afiliación
  • Corr SC; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
  • Palsson-McDermott EM; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
  • Grishina I; Department of Medical Microbiology and Immunology, University of California, Davis, CA, US.
  • Barry SP; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Aviello G; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Bernard NJ; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
  • Casey PG; Alimentary Pharmabiotic Centre, Department of Microbiology, University College Cork, Cork, Ireland.
  • Ward JB; Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
  • Keely SJ; Molecular Medicine Laboratories, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
  • Dandekar S; Department of Medical Microbiology and Immunology, University of California, Davis, CA, US.
  • Fallon PG; 1] Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland [2] Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland [3] National Children's Research Centre, Our Lady's Children's Hospital, Dub
  • O'Neill LA; 1] Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland [2] These authors contributed equally to this work.
Mucosal Immunol ; 7(1): 57-67, 2014 Jan.
Article en En | MEDLINE | ID: mdl-23612054
MyD88 adapter-like (Mal)-deficient mice displayed increased susceptibility to oral but not intraperitoneal infection with Salmonella Typhimurium. Bone marrow chimeras demonstrated that mice with Mal-deficient non-hematopoietic cells were more susceptible to infection, indicating a role for Mal in non-myeloid cells. We observed perturbed barrier function in Mal(-/-) mice, as indicated by reduced electrical resistance and increased mucosa blood permeability following infection. Altered expression of occludin, Zonula occludens-1, and claudin-3 in intestinal epithelia from Mal(-/-) mice suggest that Mal regulates tight junction formation, which may in part contribute to intestinal integrity. Mal interacted with several protein kinase C (PKC) isoforms in a Caco-2 model of intestinal epithelia and inhibition of Mal or PKC increased permeability and bacterial invasion via a paracellular route, while a pan-PKC inhibitor increased susceptibility to oral infection in mice. Mal signaling is therefore beneficial to the integrity of the intestinal barrier during infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Quinasa C / Glicoproteínas de Membrana / Receptores de Interleucina-1 / Mucosa Intestinal Límite: Animals / Humans Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Quinasa C / Glicoproteínas de Membrana / Receptores de Interleucina-1 / Mucosa Intestinal Límite: Animals / Humans Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos