Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.
Immunol Res
; 56(2-3): 304-16, 2013 Jul.
Article
en En
| MEDLINE
| ID: mdl-23609067
We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas
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Sistema Nervioso Central
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Trastornos Generalizados del Desarrollo Infantil
/
Adyuvantes Farmacéuticos
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Síndrome del Golfo Pérsico
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Aluminio
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Enfermedad de Alzheimer
/
Esclerosis Amiotrófica Lateral
Límite:
Adult
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Animals
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Child
/
Humans
/
Male
Idioma:
En
Revista:
Immunol Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos