Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn. on streptozotocin induced diabetic rats.
Asian Pac J Trop Med
; 6(4): 253-9, 2013 Apr 13.
Article
en En
| MEDLINE
| ID: mdl-23608325
OBJECTIVE: To evaluate wound healing potential of flavonoid fractions of Martynia annua (M. annua) Linn. leaves in diabetic rats on the basis of folkloric information and preliminary study. METHODS: The flavonoid compound luteolin and apigenin were isolated from dried leaves of plant by column chromatography. The two concentrations (0.2% and 0.5% w/w) of luteolin and flavonoid fraction were selected for topically applied as ointment on diabetic wound. The Povidone Iodine Ointment USP was used as a reference. On 18th days, protein content, hydroxyproline and antioxidants (SOD, CAT and GSH) level in granuloma tissues were determined. RESULTS: The results showed that, percent wound contraction were observed significantly (P<0.01) greater in MAF fraction and 0.5% w/w of luteolin treatment groups. Presence of matured collagen fibres and fibroblasts with better angiogenesis were observed in histopathological studies. CONCLUSIONS: In conclusion, our findings suggest that flavonoid fraction (MAF) and luteolin (0.5% w/w) may have potential benefit in enhancing wound healing in diabetic condition, possibly due to free-radical scavenging activity of plant.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
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Flavonoides
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Extractos Vegetales
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Pedaliaceae
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Fitoterapia
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Asian Pac J Trop Med
Año:
2013
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
India