[Elaboration of the SPM template for the standardization of SPECT images with 123I-Ioflupane]. / Elaboración de una plantilla de SPM para la normalización de imágenes de SPECT con 123I-Ioflupano.
Rev Esp Med Nucl Imagen Mol
; 32(6): 350-6, 2013.
Article
en Es
| MEDLINE
| ID: mdl-23570700
PURPOSE: Statistical parametric mapping (SPM) is a widely used produced for normalization of functional images. This study has aimed to develop a normalization template of (123)I-Ioflupane SPECT-imaging DaTSCAN(®), GE Healthcare), not available in SPM5, and to validate it compared to other quantification methods. MATERIAL AND METHODS: In order to write the template we retrospectively selected 26 subjects who had no evidence of nigrostriatal degeneration and whose age distribution was similar to that of the patients in the usual practice of our Department: 2 subjects (7.6%) were < 35 years, 9 between 35-65 years (34.6%) and 15 > 65 years (57.7%). All the studies were normalized with the T1-template available in SPM5 and an average image of the value was obtained for each voxel. For validation we analyzed 60 patients: 30 with idiopathic Parkinson's disease patients (iPD) with right involvement (66.83±12.20 years) and 30 with essential tremor patients (ET) (67.27±8.33 years). Specific uptake rates (SUR) of different striatal regions were compared after image normalization with our template and the application of a semiautomated VOIs-map created with Analyze v9.0 ((©)BIR, Mayo Clinic), against two quantification methods: a) manual adjustment of a ROIs-map drawn in Analyze, and b) semi-automated method (HERMES-BRASS) with normalization and implementation of VOIs-map. RESULTS: No statistically significant differences in the iPD/ET discriminatory capacity between the three methods analyzed were observed (p<0,001). The correlation of SUR after normalization with our «template¼ was higher than that obtained by method b) (R>0,871, p<0,001). This difference was greater in patients with PD. CONCLUSIONS: Our study demonstrates the efficacy of our SPM «template¼ for (123)I-Ioflupane SPECT-imaging, obtained from normalization with «T1-template¼.
Palabras clave
Dopamina; Dopamine; Dopamine transporters; Enfermedad de Parkinson; Mapas estadísticos paramétricos; Movement disorders; Parkinson's disease; Statistic parametric mapping; Striatal dopamine transporters; Transportadores de dopamina; Transportadores de dopamina en el estriado; Trastornos del movimiento
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Tomografía Computarizada de Emisión de Fotón Único
/
Temblor Esencial
/
Nortropanos
Tipo de estudio:
Guideline
Límite:
Adult
/
Aged
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Humans
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Middle aged
Idioma:
Es
Revista:
Rev Esp Med Nucl Imagen Mol
Año:
2013
Tipo del documento:
Article
Pais de publicación:
España