Linearity and shift invariance for quantitative magnetic particle imaging.
IEEE Trans Med Imaging
; 32(9): 1565-75, 2013 Sep.
Article
en En
| MEDLINE
| ID: mdl-23568496
Magnetic Particle Imaging (MPI) is a promising tracer imaging modality that employs a kidney-safe contrast agent and does not use ionizing radiation. MPI already shows high contrast and sensitivity in small animal imaging, with great potential for many clinical applications, including angiography, cancer detection, inflammation imaging, and treatment monitoring. Currently, almost all clinically relevant imaging techniques can be modeled as systems with linearity and shift invariance (LSI), characteristics crucial for quantification and diagnostic utility. In theory, MPI has been proven to be LSI. However, in practice, high-pass filters designed to remove unavoidable direct feedthrough interference also remove information crucial to ensuring LSI in MPI scans. In this work, we present a complete theoretical and experimental description of the image artifacts from filtering. We then propose and validate a robust algorithm to completely restore the lost information for the x-space MPI method. We provide the theoretical, simulated, and experimental proof that our algorithm indeed restores the LSI properties of MPI.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diagnóstico por Imagen
/
Nanopartículas de Magnetita
/
Modelos Teóricos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
IEEE Trans Med Imaging
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos