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Gene expression of endothelin receptors in replaced rheumatic mitral stenotic valves.
Leão, Sydney Correia; Souto, Fernanda Maria Silveira; Costa, Ricardo Vieira da; Rocha, Thaisa de Fatima Almeida; Pacheco, Yolanda Galindo; Rodrigues, Tania Maria de Andrade.
Afiliación
  • Leão SC; Laboratory of Molecular Anatomy, Department of Morphology, Biological and Health Science Center, Sergipe Federal University, São Cristóvão, SE, Brazil. sydneyleao@hotmail.com
Rev Bras Cir Cardiovasc ; 27(4): 512-9, 2012 Dec.
Article en En | MEDLINE | ID: mdl-23515723
OBJECTIVES: Rheumatic fever is a highly prevalent disease in Brazil, and it poses a major public health problem. It is the leading cause of acquired heart disease in childhood and adolescence. The aim of this study was to evaluate the gene expression of ET-3 and its receptors, in replaced rheumatic mitral valves. METHODS: We studied the gene expression of endothelin-3 (ET-3) and its receptors, endothelin receptor A and endothelin receptor B (ETr-A and ETr-B), in the rheumatic mitral valves of 17 patients who underwent valve replacement surgery. The samples also underwent a histological analysis. RESULTS: Our data showed that almost all patients, regardless of individual characteristics such as gender or age, expressed the endothelin receptor genes, but did not express the genes for ET-3. In quantitative analysis, the ETr-A/GAPDH mean ratio was 33.04 ± 18.09%; while the ETr-B/GAPDH mean ratio was 114.58 ± 42.30%. Regarding histopathological individual features, the frequency of fibrosis is 100%, 88.23% of mononuclear infiltrate, 52.94% of neovascularization, 58.82% of calcification and absence of ossification. CONCLUSION: The presence of receptors ETr-A and ETr-B in rheumatic mitral valves suggests its interaction with the system of circulating endothelins, particularly ETr-B (known for acting in the removal of excess endothelin) detected in a greater proportion, which could explain the lack of expression of endothelin in rheumatic mitral valve, process to be elucidated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiopatía Reumática / Expresión Génica / Endotelina-3 / Receptor de Endotelina A / Receptor de Endotelina B / Estenosis de la Válvula Mitral Límite: Adult / Female / Humans / Male Idioma: En Revista: Rev Bras Cir Cardiovasc Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiopatía Reumática / Expresión Génica / Endotelina-3 / Receptor de Endotelina A / Receptor de Endotelina B / Estenosis de la Válvula Mitral Límite: Adult / Female / Humans / Male Idioma: En Revista: Rev Bras Cir Cardiovasc Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil