Estramustine phosphate in secondary hormone-resistant carcinoma of the prostate.
Eur Urol
; 17(3): 216-8, 1990.
Article
en En
| MEDLINE
| ID: mdl-2351191
In this retrospective study, 71 patients with secondary hormone-refractory prostatic carcinomas were treated with estramustine phosphate (EMP), at three different dosages (280, 560, 840 mg orally). All patients were completely followed up until cancer-induced death. In 12 cases of further progression polychemotherapy was administered. As this was not a randomized study, an analysis of statistical significance was not performed. The higher dosages of EMP caused an extended progression-free interval accompanied by an equally considerable alleviation of carcinoma-induced pain. The overall survival time was not influenced by subsequent polychemotherapy. An elevation of liver function parameters was observed in 5 patients. One of these patients died of toxic liver damage, possibly therapy-related, on the basis of a preexisting cirrhosis. Cardiovascular side effects were not observed. With regard to survival time, the positioning of polychemotherapy as a third-line treatment for prostatic cancer should be examined critically. Before administration of high-dose EMP, it is mandatory to control liver functions carefully.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Carcinoma
/
Estramustina
/
Compuestos de Mostaza Nitrogenada
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Eur Urol
Año:
1990
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Suiza