The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats.
Iran J Basic Med Sci
; 15(5): 1102-5, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-23492757
OBJECTIVES: Cytokines such as IL-1ß are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1ß after traumatic brain injury (TBI) in male rats. MATERIALS AND METHODS: Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations were quantified by ELISA kits. RESULTS: Groups showed no significant difference in brain IL-10 either after TBI induction or after treatment with ibuprofen or celecoxib. Serum IL-10 in vehicle or ibuprofen treated animals was lower than in sham groups (P< 0.01). Brain IL-1ß decreased after treatment by ibuprofen or celecoxib (P< 0.001). There was no statistical difference in serum IL-1ß in TBI and intact. Serum IL-1ß significantly decreased in rats that received celecoxib compared to TBI group (P< 0.01). CONCLUSION: Based on our study IL-1ß can decrease through both cyclooxygenase 1 (COX-1) and COX-2 pathway but serum IL-1ß can decrease only by COX-2 pathway.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
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En
Revista:
Iran J Basic Med Sci
Año:
2012
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Irán