The study of enantioselectivity of all regioisomers of mono-carboxymethyl-ß-cyclodextrin used as chiral selectors in CE.
J Sep Sci
; 36(7): 1270-4, 2013 Apr.
Article
en En
| MEDLINE
| ID: mdl-23483743
This work documents the influence of the position of single carboxymethyl group on the ß-cyclodextrin skeleton on the enantioselectivity. These synthesized monosubstituted carboxymethyl cyclodextrin (CD) derivatives, native ß-cyclodextrin, and commercially available carboxymethyl-ß-cyclodextrin with degree of substitution approximately 3 were used as additives into the BGE consisting of phosphate buffer at 20 mmol/L concentration, pH 2.5, and several biologically significant low-molecular-mass chiral compounds were enantioseparated by CE. The results indicate that different substituent location on ß-cyclodextrin skeleton has a significant influence on the enantioseparation of the investigated enantiomers. The enantioselectivity of 2(I)-O-regioisomer was better than with native ß-cyclodextrin. Comparable results to native ß-cyclodextrin were obtained for 6(I)-O- regioisomer and the enantioselectivity of 3(I)-O-regioisomer was even worse than with native ß-cyclodextrin. Commercially available derivative of CD provides better resolutions than the monosubstituted carboxymethyl CD derivatives for most of the investigated analytes.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Sep Sci
Año:
2013
Tipo del documento:
Article
País de afiliación:
República Checa
Pais de publicación:
Alemania