Kolaviron prevents carbendazim-induced steroidogenic dysfunction and apoptosis in testes of rats.
Environ Toxicol Pharmacol
; 35(3): 444-53, 2013 May.
Article
en En
| MEDLINE
| ID: mdl-23474402
The study evaluated the protective role of kolaviron (an isolated biflavonoid from the seed of Garcinia kola) and vitamin E in carbendazim-induced reproductive dysfunction in male rats. Adult male Wistar rats were orally exposed to carbendazim (200mg/kg) singly or in combination with kolaviron (100 and 200mg/kg). Exposure to carbendazim significantly decreased the activities of superoxide dismutase and catalase but markedly increased sialic acid concentration and lipid peroxidation in the testes of rats. Western blot analysis revealed that carbendazim treatment decreased the expression of steroid acute regulatory (StAR) protein and androgen binding protein (ABP) with concomitant decrease in activities of steroidogenic enzymes. Germ cell apoptosis in carbendazim-treated rats was confirmed by TUNEL assay. However, pretreatment with kolaviron and vitamin E restored the testicular antioxidant status and steroidogenesis and decreased apoptotic nuclei to near control level in carbendazim-treated rats. Kolaviron may prove useful in combating carbendazim-induced reproductive toxicity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Testículo
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Bencimidazoles
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Flavonoides
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Carbamatos
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Fungicidas Industriales
Límite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2013
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Países Bajos