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Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study.
McMillan, D J; Drèze, P-A; Vu, T; Bessen, D E; Guglielmini, J; Steer, A C; Carapetis, J R; Van Melderen, L; Sriprakash, K S; Smeesters, P R.
Afiliación
  • McMillan DJ; Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research, Brisbane, Qld, Australia.
Clin Microbiol Infect ; 19(5): E222-9, 2013 May.
Article en En | MEDLINE | ID: mdl-23464795
Group A Streptococcus (GAS) M protein is an important virulence factor and potential vaccine antigen, and constitutes the basis for strain typing (emm-typing). Although >200 emm-types are characterized, structural data were obtained from only a limited number of emm-types. We aim to evaluate the sequence diversity of near-full-length M proteins from worldwide sources and analyse their structure, sequence conservation and classification. GAS isolates recovered from throughout the world during the last two decades underwent emm-typing and complete emm gene sequencing. Predicted amino acid sequence analyses, secondary structure predictions and vaccine epitope mapping were performed using MUSCLE and Geneious software. A total of 1086 isolates from 31 countries were analysed, representing 175 emm-types. emm-type is predictive of the whole protein structure, independent of geographical origin or clinical association. Findings of an emm-type paired with multiple, highly divergent central regions were not observed. M protein sequence length, the presence or absence of sequence repeats and predicted secondary structure were assessed in the context of the latest vaccine developments. Based on these global data, the M6 protein model is updated to a three representative M protein (M5, M80 and M77) model, to aid in epidemiological analysis, vaccine development and M protein-related pathogenesis studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Proteínas Portadoras / Antígenos Bacterianos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Proteínas Portadoras / Antígenos Bacterianos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2013 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido